Chemical Synthesis Services

Chemokines

CSS is the 
company of choice for Chemokines

We provide Chemokines of

  • High quality >95% by HPLC
  • Researcher defined
  • Tailored to meet your every requirement :
      - Biotin tagging
      - Fluorescent tagging
      - Chemokine analogues

X-ray crystal structure of HCC-1 synthesised & purified by Prof Ramage & his team

Chemokines constitute a super-family of small, inducible, secreted, pro-inflammatory cytokines involved in a variety of immune responses, acting primarily as chemoattractants and activators of specific types of leukocytes.

Four classes of chemokines have been defined by the arrangement of the conserved cysteine (C) residues of the mature proteins:

  • CXC chemokines : with one amino acid residue separating the first two conserved cysteine residues;
  • CC chemokines : in which the first two conserved cysteines residues are adjacent;
  • C chemokines : these lack two (the first and third) of the four conserved cysteine residues; and
  • CX3C chemokines : these have three intervening amino acid residues between the first two conserved cysteine residues.

    Chemokines mediate their activities by binding to target cell surface chemokine receptors that belong to the large family of G protein-coupled, seven transmembrane domain receptors.

    CSS uses novel technologies developed for the synthesis of long peptides to chemically synthesise members of the chemokine family. It uses special folding conditions to produce biologically active chemokines and has now synthesised and purified more than 20 wild type and modified chemokines.

    Chemical synthesis allows the production of chemokines that are very difficult, if not impossible, to produce recombinantly. It also opens up the opportunity to site specifically modify the wild type, eg to improve the design of potential therapeutic candidates or to fluorescently label or biotinylate chemokines for a variety of applications including assay development, diagnostics and basic research.

    CSS offers custom based synthesis of chemokine proteins, and site specific modifications. Our products include:

    Wild Type Modified
    Human: Human
    MCP-1 CCL2 IL8 - labelled
    MIP-1α CCL3 MIP-1α - biotin
    MCP-1β CCL4 MIP-1α - flurescein
    RANTES CCL5  
    Eotaxin CCL11 Guinea pig:
    HCC-1 CCL14 Eotaxin - biotin
    IL-8 CXCL8 Eotaxin - fluorescein
        Eotaxin - C-terminal modification
    Cynomolgus eotaxin CCL11  
    Guinea pig eotaxin CCL11 Murine:
    Rat MCP-1 CCL2 Eskine - biotin

    Whatever your chemokine requirements, give the synthesis specialists a call at CSS.

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