Chemical Synthesis Services

Company Profile

Custom Synthesis and API manufacturing company, CSS, acquired a controlling interest in Albachem - a world leading peptide synthesis company servicing the pharmaceutical and biotechnology industries, on the 26^th of March 2004.

The strategic acquisition will strengthen the R&D work underway at the Albachem site and further develop the service offering to global clients and the company's provision of niche speciality areas to pharmaceutical industry.

For further information on CSS, please click on the following link to our main website; www.css-almac.com

Prior to the acquisition Albachem was a privately owned biotechnology company based in Edinburgh, Scotland. The new company is an established provider of custom peptides and proteins, with an innovative protein-based research programme, backed by a world leader in the field.

Custom synthesis......size is no longer an issue

Using proprietary techniques pioneered by Professor Ramage and his expert team of protein chemists in Edinburgh, it is now possible to chemically synthesise proteins up to 170 residues in length with all the advantages of speed and purity only possible previously with much smaller peptides.

Peptides ...... applications

Peptides are essential tools for a variety of molecular biological applications. These include:

• Production of monoclonal and polyclonal antibodies
• Development of therapeutic candidates and vaccines
• Diagnostics and assays
• Structure function studies
• Epitope mapping
• Peptidomimetics

Why chemical synthesis?

Peptides cannot always be extracted from natural sources or expressed in sufficient quantities. In addition recombinant proteins are contaminated with endotoxins. Chemically synthesised peptides have no endotoxins, an important factor for GMP production of proteins.

In addition, chemical synthesis allows the incorporation of site specific modifications giving the customer full control over the primary sequence of the protein. This includes the inclusion of unnatural amino acids at particular locations, eg site specific mutations for protein-ligand binding, fluorescent probes and affinity tags for assay development and diagnostics.

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